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KMID : 0380620220540050463
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Korean Journal of Food Science and Technology
2022 Volume.54 No. 5 p.463 ~ p.467
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Anti-wrinkle activity of ethyl acetate fraction of rutin treated with subcritical water
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Jo Yeon-Jae
Yoo Dan-Hee
Lee In-Chul
Lee Jun-Soo
Jeong Heon-Sang
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Abstract
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This study evaluated the anti-wrinkle activity of rutin treated at high temperatures and pressures. Different treatment temperatures and pressures were 200°C and 15 bar, 300°C and 100 bar, and 400°C and 250 bar, respectively. The collagenase inhibitory activity of each treated rutin ranged from 27.07-70.67% at a concentration of 1 mg/mL. Procollagen type-1 synthesis of the ethyl acetate fraction showed a 95.53% higher production rate than that of the control at a concentration of 50 μg/mL. The protein expression of Matrix metalloproteinase (MMP)-1 and MMP-3 was decreased by 68.59 and 33.36%, respectively, compared to that in controls at concentrations of 50 μg/mL ethyl acetate fractions. These results suggest that high-temperature and high-pressure treatment technologies can be used to develop functional food and cosmetic materials with anti-wrinkle activity.
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KEYWORD
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subcritical water, ethyl acetate fraction, rutin, anti-wrinkle, collagen
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